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  • Potentially Treatable Condition
  • Nervous System
  • Essential Tremor

ESSENTIAL TREMOR

INTRODUCTION

Essential Tremor: Essential tremor (ET) is a neurological condition where an individual experiences uncontrollable and involuntary shaking that can affect almost any part of the body including hands, head, voice, arms and legs.

Comparison of spiral drawing between individual with essential tremor and healthy control

ESSENTIAL TREMOR

Essential tremor is a neurological disorder that causes involuntary shaking or trembling in different parts and sides of the body. 

A theory suggests that the cerebellum, controlling muscle coordination, is not communicating correctly with other parts of the brain.

​The cause of this illness remains unknown however, genetics are strongly suspected as one of the main causes.

SYMPTOMS OF ESSENTIAL TREMOR ESSENTIAL TREMOR

    • The voluntary muscles that are consciously moved are affected
    • Nodding of the head if the head is affected
    • If the larynx or voice box is affected, a shaky and quivering voice can be detected
    • A small and rapid tremor
    • Tremor that is worsened by an activity or movement
    • Tremor that stops or lessens when the certain body part affected is at rest
    • Tremor that stops when asleep
    • Tremor that increases as one gets older
    • Most of the time, the hands, head and voice are affected
    • Other parts of the body such as arms and eyelids might also be affected with time

WHAT CAUSES THE DISEASE? THE DISEASE?

MSC clinical applications Avascular necrosis.

​MSCs have clinical applications for treating avascular necrosis of the hip. Avascular necrosis of the hip is a pathological condition caused by a disruption in blood supply to the femoral head. MSCs can be used to supplement the core decompression procedure, which is designed to relieve intraosseous pressure while also promoting new bone formation and angiogenesis. Some early studies using whole bone marrow transplantation have found a link between the number of osteoprogenitor cells and the outcome.

CURRENT TREATMENTS TREATMENTS

Medications and injections currently used to treat essential tremor:

MEDICATION

FUNCTION

LIMITATION

Beta Blockers

Beta blockers such as propranolol help relieve tremors 

    • Not a good option for individuals with asthma or certain heart problems 
    • Side effects may include fatigue, lighthead-edness or heart problems

Anti-Seizures

    • Epilepsy drugs may be effective in individuals who don’t respond to beta blockers
    • Other medications that might be prescribed include gabapentin and topiramate

Side effects include drowsiness and nausea, which usually disappear within a short time

Tranquilizers

Benzodiazepine drugs such as clonazepam may be used to treat individuals whose tension or anxiety worsens tremors 

    • Side effects can include fatigue or mild sedation
    • Should be used with caution because they can be habit-forming

Botox Injections

    • Might be useful in treating some types of tremors, especially head and voice tremors
    • One injection can improve tremors for up to three months at a time
    • If used to treat hand tremors, it can cause weakness in the fingers 
    • If used to treat voice tremors, it can cause a hoarse voice and difficulty swallowing

Nerve stimulation devices

SURGERY

Therapy is also one of the treatment options to treat essential tremor

    • A wearable electronic peripheral nerve stimulation device is a newer form of treatment option for people with essential tremor
    • The device that can be worn works by stimulating peripheral nerves and muscles to create a muscle response that reduces tremors. Studies have found that the device can bring some improvement for tremors
    • Limitations of the new nerve stimulation device is that it takes too long for only small improvements to show
    • Deep brain stimulation
    • Focused ultrasound thalamotomy
    • Disadvantages of surgeries are the risks of complications and the costly procedures 
    • Physical therapy is where exercises are taught in order to increase muscle strength, coordination and control
    • Occupational therapy provides devices to help an individual with essential tremor adapt and reduce its effects
    • Disadvantages of therapy include only improving the symptoms of essential tremors and not targeting the root of the cause

WHAT WE OFFER? OFFER?

EXOSOME RESEARCH - CELLTIX CELLTIX

CelltiX is a type of extracellular vesicle from Umbilical Cord-Derived Mesenchymal Stem Cells (MSCs) manufactured in a cGMP-compliant facility.

It is a novel form of a major paracrine factor released by MSCs into a culture medium, which plays an important role in a wide range of biological processes.

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STEM CELL RESEARCH - CELLTIMAX CELLTIMAX

CelltiMax is a product derived from human umbilical cord-derived Mesenchymal Stem Cells (MSCs). The cells are cultured, then administered to the patient via intramuscular or intravenous injection. They have the ability to differentiate into specialized cells with specific functions for various parts of the body, and can reduce inflammation, repair, renew, regenerate, and replace damaged cells.

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COMPARISON BETWEEN STEM CELLS AND EXOSOMES AND EXOSOMES

​CRITERIAS

​STEM CELLS

​EXOSOME

​Definition

Stem cells are unspecialized cells of the human body.

Extracellular vesicles, which is the medical term for tiny bubbles that are released from stem cells.

Function

Unique, can become any type of cell, and they act as both building blocks and repair mechanisms in your body.

Carry genetic information and proteins to cells throughout your body, and they create paths for communication between cells.

​Origins

Donor stem cells are placed in your body and are guided into becoming specific cells in the body to replace and repair diseased cells.

Exosomes are extracted from donated human mesenchymal stem cells (MSCs) and sterilized.

​Growth Factors

Less amount of growth factors compared to exosomes.

Exosomes contain nearly three times the amount of growth factors. More growth factors mean a better ability to restore and revitalize target cells.

​Administration

    • IV Stem Cell Research (Intravenous administration)
    • Intrathecal (directly into the spinal canal)
    • Site injections into problem areas (Knee, hips, hands, etc)
    • Intravenous (IV) research
    • Direct injection in the treatment area

BENEFITS OF OUR TREATMENTS OUR TREATMENTS

STEM CELL RESEARCH

EXOSOME RESEARCH

​Improve bodies’ natural healing abilities

High stabililty

Modulate the immune system

Low toxicity and immunogenicity

Locate and reduce areas of inflammation

High penetration

​Replace damaged and diseased cells

Enhanced delivery efficiency

HOW IT WORKS? WORKS?

STEM CELL RESEARCH (CELLTIMAX)

How stem cells can help decrease and repair damages caused by neurodegenerative diseases

​Previous studies on stem cells have shown that the effects of stem cells on endogenous cells include: 

    • Promotion of functional recovery of nervous tissue, 
    • differentiation into neuronal and glial cells,
    •  Reduction of motor impairments. 

These cells can develop into neural progenitor cells (NPCs) and mesenchymal stem cells (MSCs), from which brain cells of various neuronal and glial lineages, including oligodendrocytes and astrocytes, can be produced.

EXOSOME RESEARCH (CELLTIX) 

MSC clinical applications Avascular necrosis.

Exosomes function as tiny messengers that provide vital genetic data, proteins, and messenger RNA to cells throughout our body. They aid in information transmission between cells and improve cell communication.

It has been demonstrated that exosomes from youthful stem cells can rejuvenate older stem cells in our bodies, help control a hyperactive immune system, and modify the immune system so that it works more efficiently and cogently. 

Because of its anti-inflammatory and immunomodulating properties, exosome treatment has been proven to be helpful for treating essential tremors.

TALK TO US

​If you feel we might be able to offer meaningful improvement to both your condition and your quality of life, then please reach out to schedule a free consultation with one of our in-house clinical experts. We offer consultations in both Malay and English. 

To schedule your consultation, click the button below

Book Now >

​During your consultation, we will: we will:

Review your medical history & recent evaluations

Explore what your treatment package might look like​

Answer any questions you have about us

Answer any questions you have about the therapies

Discuss practical next steps, ​if you feel we can effectively treat you

Review your medical history & recent evaluations

Explore what your treatment package might look like​

Answer any questions you have about us

Answer any questions you have about the therapies

Discuss practical next steps,
​if you feel we can effectively treat you

CELL TISSUE TECHNOLOGY SDN BHD

Malaysia's FIRST Tissue Engineering Firm

Established in 2010, Cell Tissue is a Malaysian advanced medical technologybased company, a spin-off of the National University of Malaysia (UKM), one of the country’s leading universities and research institutes.

Cell Tissue is known as Malaysia’s FIRST Tissue Engineering Firm, awarded by the prestigious Malaysian Book of Records in 2016, operated in a certified Current Good Manufacturing Practice (cGMP) laboratory following PIC/S standards by the National Pharmaceutical Regulatory Agency (NPRA), a division of the Ministry of Health Malaysia.

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