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Inside the bloodstream, NK cells are constantly interacting with other cells. The decision of whether or not an NK cell kills these cells is determined by a balance of signals from activating receptors and inhibitory receptors on the surface of the cell. Activating receptors recognize molecules that are expressed on the surface of cancer cells and infected cells, leading to the activation of the NK cell. Inhibitory receptors act as a control mechanism for NK cell killing.
MHC-I receptors are expressed by normal, healthy cells as a marker that these cells are “self.” Inhibitory receptors on the surface of the NK cell recognize cognate MHC I, preventing the NK cell from activating and killing. Cancer cells and infected cells often lose their MHC I, making them vulnerable to killing by NK cells. Once the decision to kill is made, the NK cell releases cytotoxic granules containing perforin and granzymes, resulting in the lysis of the target cell.
Patients who lack NK cells and cytotoxicity are highly susceptible to viruses, pathogens, senility, and cancer.
CelltiNK is a form of Immunotherapy that uses Natural Killer cells to fight cancers and infections in patients. This research has developed memory-like NK cells which can:
*Each patient is attended to on a case-to-case basis. Treatment will vary for each patient
If you feel we might be able to offer meaningful improvement to both your condition and your quality of life, then please reach out to schedule a free consultation with one of our in-house clinical experts. We offer consultations in both Malay and English.
Established in 2010, Cell Tissue is a Malaysian advanced medical technologybased company, a spin-off of the National University of Malaysia (UKM), one of the country’s leading universities and research institutes.
Cell Tissue is known as Malaysia’s FIRST Tissue Engineering Firm, awarded by the prestigious Malaysian Book of Records in 2016, operated in a certified Current Good Manufacturing Practice (cGMP) laboratory following PIC/S standards by the National Pharmaceutical Regulatory Agency (NPRA), a division of the Ministry of Health Malaysia.
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