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CelltiGraft

CELLTIGRAFT®

CELLTIGRAFT® is an Autologous Bilayer Tissue Engineered Human Skin (TEHS) used to treat and manage skin loss injury and wounds. It is completely compatible with patients with zero chance of rejection.
 
CELLTIGRAFT® is constructed of 1 to 2 millions of fibroblasts and keratinocytes cells which are embedded in human plasma.

CELLTIGRAFT® is applicable as an alternative in the treatment of:​​

    • Huge skin loss due to major burns
    • Non-healing or recurring ulcers
    • Full thickness skin loss due to trauma 
    • Skin loss due to other medical causes

HOW IS CELLTIGRAFT® PRODUCED?

    • CELLTIGRAFT® can be constructed from a single 1 x 3 cm elliptical skin biopsy then processed with enzymes to produce fibroblasts and keratinocytes. These cells are extracted, cultured and expanded.​
    • HPD extracted from patient’s own blood (autologous) is used as the biomaterial scaffold for constructing the CelltiGraft . This process creates the 3-Dimensional structure of CelltiGraft  providing the ideal bilayer skin substitute for treating skin loss.
    • The cell culturing process will only take 4 to 6 weeks for producing 1 to 2 millions of fibroblasts and keratinocytes cells per 100 cm2 skin construct.

CELLTIGRAFT® TRANSPLANTATION METHOD

    • Sterile environment is required for implantation of CELLTIGRAFT® preferably inside of sterile Operation Theater.
    • Before implantation of CELLTIGRAFT®, a few nick had to be done using scalpel for fenestration of blood or serous from surgical wound site.
    • CELLTIGRAFT® can be secured at the implanted site using absorbable suture or staple.
    • HPD extracted from patient’s own blood (autologous) is used as the biomaterial scaffold for constructing the CelltiGraft . This process creates the 3-Dimensional structure of CelltiGraft  providing the ideal bilayer skin substitute for treating skin loss.
    • The cell culturing process will only take 4 to 6 weeks for producing 1 to 2 millions of fibroblasts and keratinocytes cells per 100 cm2 skin construct.

celltigraft®​ CASE STUDY

COMPARISON OF CELLTIGRAFT® AND MYDERM®​

 

CHARACTERISTICS
MYDERM®​
​CELLTIGRAFT®​
Number of Cells
More
Less
​​Duration to Construct
​Approx. 6 weeks
​Approx. 3 weeks
​HPD Biomaterial
Yes
Yes
​Ingredients
​​Fibroblast and Keratinocytes
Fibroblast and Keratinocytes
​Scaffold
​Patient’s Own Blood
Patient’s Own Blood
Autologous
Yes
Yes
​Associated with Growth Factors
More
Less
​ Mimic Native Skin
Yes
Yes
​Preservation & Re-culture
Yes
Yes
​Permanent Skin Substitute
Yes
Yes
Number of Surgery
One
One
​SSG Procedure
No
No
Source of Substance
​Patient’s Own Cells
​​Patient’s Own Cells

WHY CHOOSE CELLTIGRAFT®

    • Autologous, so unlikely to cause any rejection or immunological reaction.
    • Bilayer characteristic in CELLTIGRAFT® means it mimics the native skin layer of the dermis and epidermis.
    • HPD biomaterial used in CELLTIGRAFT® production is made of natural molecule which is also autologous and will easily degrade into the body host after implantation.
    • Functions as a permanent coverage of wound.
    • Able to cover a large wound without the need to harvest from big donor area.
    • Able to restore the barrier function of damaged or burned skin.
    • Has the ability to secrete growth factors, enzymes and biochemical to mimic the physiological activity of the skin, hence promote rapid wound healing.
    • Results in better cosmesis by improving the quality of scarring and pigmentation.

INDICATION FOR CELLTIGRAFT®

CELLTIGRAFT® is used in a wide variety of skin loss due to trauma, burning, chronic non-healing ulcer, orthopedic, and also in plastic and reconstructive surgery.

PRODUCT DELIVERY

    • CELLTIGRAFT® is delivered and stored inside a cooler box to maintain the temperature between 4℃ to 8℃ in sterile package.
    • CELLTIGRAFT® must be used within 24 hours at temperature between 4℃ and to 8℃​.
    • CELLTIGRAFT® handling is strictly under aseptic precaution.

SHELF LIFE

CELLTIGRAFT® must be used within 3 DAYS from its final construct date.

CITATIONS

1. Law, J. X., Chowdhury, S. R., Aminuddin, B. S., & Ruszymah, B. H. I. (2017). Role of plasma-derived fibrin on keratinocyte and fibroblast wound healing. Cell and tissue banking, 18(4), 585-595.

2. Idrus, R. H., bin P Rameli, M. A., Low, K. C., Law, J. X., Chua, K. H., Latiff, M. B. A., & Saim, A. B. (2014). Full-thickness skin wound healing using autologous keratinocytes and dermal fibroblasts with fibrin: bilayered versus single-layered substitute. Advances in Skin & Wound Care, 27(4), 171-180.

3. Busra M. F., Chowdhury S. R., bin Ismail F., bin Saim A., Idrus R. B. (2016). Tissue-engineered skin substitute enhances wound healing after radiation therapy. Advances in skin & wound care, 29(3), 120-129.

4. Maarof, M., Law, J. X., Chowdhury, S. R., Khairoji, K. A., Saim, A. B., & Idrus, R. B. H. (2016). Secretion of wound healing mediators by single and bi-layer skin substitutes. Cytotechnology, 68(5), 1873-1884.

5. Law, J. X., Musa, F., Ruszymah, B. H. I., El Haj, A. J., & Yang, Y. (2016). A comparative study of skin cell activities in collagen and fibrin constructs. Medical engineering & physics, 38(9), 854-861.

6. Ishak, M.F., Maarof, M., Ng, M.H., Khairul, B., Gargy, L., Aminuddin, B.S. (2019).Long Term Effect of Cryopreservation on Primary Human Skin Cells. Sains Malaysiana, 48 (1), 137-144.

CELL TISSUE TECHNOLOGY SDN BHD

Malaysia's FIRST Tissue Engineering Firm

Established in 2010, Cell Tissue is a Malaysian advanced medical technologybased company, a spin-off of the National University of Malaysia (UKM), one of the country’s leading universities and research institutes.

Cell Tissue is known as Malaysia’s FIRST Tissue Engineering Firm, awarded by the prestigious Malaysian Book of Records in 2016, operated in a certified Current Good Manufacturing Practice (cGMP) laboratory following PIC/S standards by the National Pharmaceutical Regulatory Agency (NPRA), a division of the Ministry of Health Malaysia.

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