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CelltiX Nebulizer

How CelltiX Help Reduce Symptoms of COVID-19?

RESEARCH TEAM FROM ​CELL TISSUE TECHNOLOGY

COLLABORATION WITH RESEARCH UNIVERSITIES

In addition, many leading universities and research centres in Malaysia are actively involved in conducting research on the potential of bioactive factors for clinical use. Among them are:

References

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  2. Gurunathan, S., Kang, M. H., & Kim, J. H. (2021). Diverse effects of exosomes on COVID-19: A perspective of progress from transmission to therapeutic developments. Frontiers in Immunology, 12. https://www.frontiersin.org/articles/10.3389/fimmu.2021.716407/full
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  11. Yu, B., Zhang, X., & Li, X. (2014). Exosomes derived from mesenchymal stem cells. International journal of molecular sciences, 15(3), 4142–4157. https://doi.org/10.3390/ijms15034142. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975389/
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  14. Garis Panduan KKM Post-COVID-19. https://covid-19.moh.gov.my/garis-panduan/garis-panduan-kkm/ANNEX_50_POST_COVID-19_MANAGEMENT_PROTOCOL_12JULY2021.pdf
  15. Jayaramayya, K., Mahalaxmi, I., Subramaniam, M. D., Raj, N., Dayem, A. A., Lim, K. M., Kim, S. J., An, J. Y., Lee, Y., Choi, Y., Raj, A., Cho, S. G., & Vellingiri, B. (2020). Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment. BMB reports, 53(8), 400–412. https://doi.org/10.5483/BMBRep.2020.53.8.121. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473478/
  16. Gurunathan, S., Kang, M. H., & Kim, J. H. (2021). Diverse effects of exosomes on COVID-19: A perspective of progress from transmission to therapeutic developments. Frontiers in Immunology, 12. https://www.frontiersin.org/articles/10.3389/fimmu.2021.716407/full
  17. Drew, D. A., Guo, C. G., Lee, K. A., Nguyen, L. H., Joshi, A. D., Lo, C. H., … & Chan, A. T. (2021). Aspirin and NSAID use and the risk of COVID-19. medRxiv. https://covid-19.cochrane.org/studies/crs-13265944
  18. Gardin, C., Ferroni, L., Chachques, J. C., & Zavan, B. (2020). Could Mesenchymal Stem Cell-Derived Exosomes Be a Therapeutic Option for Critically Ill COVID-19 Patients?. Journal of clinical medicine, 9(9), 2762. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565764/
  19. Bari, E., Ferrarotti, I., Saracino, L., Perteghella, S., Torre, M. L., Richeldi, L., & Corsico, A. G. (2021). Mesenchymal Stromal Cell Secretome for Post-COVID-19 Pulmonary Fibrosis: A New Research to Treat the Long-Term Lung Sequelae?. Cells, 10(5), 1203. https://doi.org/10.3390/cells10051203. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155949/
  20. The Jerusalem Post. https://www.jpost.com/health-science/covid-90-percent-of-patients-treated-with-new-israeli-drug-discharged-in-5-days-67596
  21. Lee, J. H., Park, J., & Lee, J. W. (2019). Therapeutic use of mesenchymal stem cell-derived extracellular vesicles in acute lung injury. Transfusion, 59(S1), 876–883. https://doi.org/10.1111/trf.14838. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368889/
  22. Abdelgawad, M., Bakry, N. S., Farghali, A. A., Abdel-Latif, A., & Lotfy, A. (2021). Mesenchymal stem cell-based research and exosomes in COVID-19: current trends and prospects. Stem cell research & research, 12(1), 1-20. https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02542-z#citeas
  23. Schulman, I. H., Balkan, W., & Hare, J. M. (2018). Mesenchymal stem cell research for aging frailty. Frontiers in nutrition, 5, 108. https://www.frontiersin.org/articles/10.3389/fnut.2018.00108/full
  24. Srinivasan, A., & Sundar, I. K. (2021). Recent updates on the role of extracellular vesicles in the pathogenesis of allergic asthma. Extracellular vesicles and circulating nucleic acids, 2, 127–147. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372030/
  25. Maremanda, K. P., Sundar, I. K., & Rahman, I. (2019). Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. Toxicology and applied pharmacology, 385, 114788. https://doi.org/10.1016/j.taap.2019.114788. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894395/
  26. Xu, B., Gan, C. X., Chen, S. S., Li, J. Q., Liu, M. Z., & Guo, G. H. (2020). BMSC-derived exosomes alleviate smoke inhalation lung injury through blockade of the HMGB1/NF-κB pathway. Life sciences, 257, 118042. https://doi.org/10.1016/j.lfs.2020.118042. https://pubmed.ncbi.nlm.nih.gov/32621926/
  27. Panagiotou, N., Neytchev, O., Selman, C., & Shiels, P. G. (2018). Extracellular Vesicles, Ageing, and Therapeutic Interventions. Cells, 7(8), 110. https://doi.org/10.3390/cells7080110. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115766/
  28. Clinical Trial NCT04491240. ​https://www.clinicaltrials.gov/ct2/show/results/NCT04491240
  29. Chu, M., Wang, H., Bian, L., Huang, J., Wu, D., Fei, F., … & Xia, J. (2020). Nebulization Research for COVID-19 Pneumonia with Embryonic Mesenchymal Stem Cells-Derived Exosomes. https://europepmc.org/article/PPR/PPR233088
  30. Zambrano, G. M. T., Ahmed, Y. M., Carmenate, Y. V., & Elsadawy, M. E. (2021). Stem cell nebulization research for COVID-19 infection: radiological and clinical outcomes. Egyptian Journal of Radiology and Nuclear Medicine, 52(1), 1-11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079845/pdf/43055_2021_Article_492.pdf
  31. Alzahrani, F. A., Saadeldin, I. M., Ahmad, A., Kumar, D., Azhar, E. I., Siddiqui, A. J., … & Jahan, S. (2020). The potential use of mesenchymal stem cells and their derived exosomes as immunomodulatory agents for COVID-19 patients. Stem Cells International, 2020. https://www.hindawi.com/journals/sci/2020/8835986/​

CELL TISSUE TECHNOLOGY SDN BHD

Malaysia's FIRST Tissue Engineering Firm

Established in 2010, Cell Tissue is a Malaysian advanced medical technologybased company, a spin-off of the National University of Malaysia (UKM), one of the country’s leading universities and research institutes.

Cell Tissue is known as Malaysia’s FIRST Tissue Engineering Firm, awarded by the prestigious Malaysian Book of Records in 2016, operated in a certified Current Good Manufacturing Practice (cGMP) laboratory following PIC/S standards by the National Pharmaceutical Regulatory Agency (NPRA), a division of the Ministry of Health Malaysia.

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