ANGIOGENESIS

INTRODUCTION

Angiogenesis: ​The formation of new blood vessels is known as angiogenesis. Endothelial cells, which line the inside wall of blood vessels, migrate, grow, and differentiate during this process.

ANGIOGENESIS ANGIOGENESIS

Angiogenesis is the process by which the body creates new blood vessels.

​This is a normal part of the healing and growth process. Angiogenesis can, however, play a role in diseases such as cancer.

SYMPTOMS SYMPTOMS

Symptoms of angiogenesis vary according to types of diseases. Listed below are several examples of  diseases associated with angiogenesis and the symptoms to look out for:

DISEASE

SYMPTOMS

Diabetic retinopathy

Loss of vision

Rheumatoid arthritis

Pain and immobility from destroyed cartilage

Atherosclerotic plaques

Chest pain and dyspnoea

Endometriosis

Abdominal pain from intraperitoneal bleeding

Crohn’s disease

Intestinal bleeding

Psoriasis

Persistent severe itching

Uterine fibroids

Vaginal bleeding and abdominal bleeding

Benign prostatic hypertrophy

Urinary retention

Cancer

Bleeding, thrombosis, anaemia. abdominal ascites, bone pain, seizures from cerebral oedema around the tumor and others

CURRENT TREATMENTS TREATMENTS

Numerous angiogenesis inhibitors have received FDA approval for the treatment of cancer. VEGF, its receptor, or other particular molecules involved in angiogenesis were the focus of the majority of these targeted therapies. Among the approved inhibitors of angiogenesis are:

  • Axitinib (Inlyta®)
  • Bevacizumab (Avastin®)
  • Cabozantinib (Cometriq®)
  • Everolimus (Afinitor®)
  • Lenalidomide (Revlimid®)
  • Lenvatinib mesylate (Lenvima®)
  • Pazopanib (Votrient®)
  • Ramucirumab (Cyramza®)
  • Regorafenib (Stivarga®)
  • Sorafenib (Nexavar®)
  • Sunitinib (Sutent®)
  • Thalidomide (Synovir, Thalomid®)
  • Vandetanib (Caprelsa®)
  • Ziv-aflibercept (Zaltrap®)
aNGIOGENESIS V2

Hemorrhage, blood clots in the arteries that can lead to stroke or heart attack, hypertension, delayed wound healing, reversible posterior leukoencephalopathy syndrome, a brain condition, and protein in the urine are all potential side effects of VEGF-targeting angiogenesis inhibitor research.​ Additionally, fistulas and intestinal perforations seem to be uncommon side effects of several angiogenesis inhibitors.

​The VEGF receptor-targeting anti-angiogenesis drugs also cause fatigue, diarrhea, biochemical hypothyroidism, hand-foot syndrome, heart failure, and hair abnormalities.

WHAT WE OFFER? OFFER?

EXOSOME RESEARCH - CELLTIX CELLTIX

CelltiX is a type of extracellular vesicle from Umbilical Cord-Derived Mesenchymal Stem Cells (MSCs) manufactured in a cGMP-compliant facility.

It is a novel form of a major paracrine factor released by MSCs into a culture medium, which plays an important role in a wide range of biological processes.

STEM CELL RESEARCH - CELLTIMAX CELLTIMAX

CelltiMax is a product derived from human umbilical cord-derived Mesenchymal Stem Cells (MSCs). The cells are cultured, then administered to the patient via intramuscular or intravenous injection. They have the ability to differentiate into specialized cells with specific functions for various parts of the body, and can reduce inflammation, repair, renew, regenerate, and replace damaged cells.

COMPARISON BETWEEN STEM CELLS AND EXOSOMES AND EXOSOMES

CRITERIAS

STEM CELLS

EXOSOMES

Definition

​​Stem cells are unspecialized cells of the human body.

 

​​Extracellular vesicles, which is the medical term for tiny bubbles that are released from stem cells.

Function

​Unique, can become any type of cell, and they act as both building blocks and repair mechanisms in your body.

​Carry genetic information and proteins to cells throughout your body, and they create paths for communication between cells.

Origins

​Donor stem cells are placed in your body and are guided into becoming specific cells in the body to replace and repair diseased cells.

​Exosomes are extracted from donated human mesenchymal stem cells (MSCs) and sterilized.

Growth Factors

​Less amount of growth factors compared to exosomes.

​Exosomes contain nearly three times the amount of growth factors. More growth factors mean a better ability to restore and revitalize target cells

Administration

  • ​IV Stem Cell Research (Intravenous administration)
  • Intrathecal (directly into the spinal canal)
  • Site injections into problem areas (Knee, hips, hands, etc)
  • Intravenous (IV) research
  • Direct injection in the treatment area​

BENEFITS OF OUR TREATMENTS OUR TREATMENTS

STEM CELL RESEARCH

EXOSOME RESEARCH

​Improve bodies’ natural healing abilities

High stabililty

Modulate the immune system

Low toxicity and immunogenicity

Locate and reduce areas of inflammation

High penetration

​Replace damaged and diseased cells

Enhanced delivery efficiency

HOW IT WORKS? WORKS?

tumor-anti-angiogenesis-induced-by-mesenchymal-stem-cell-msc-a-the-gross-image-and-1

The tumor anti-angiogenesis processes induced by mesenchymal stem cell (MSC)

​Mesenchymal Stem Cells (MSCs) have been shown to alter the tumor microenvironment to reduce angiogenesis or neovascularization. In addition to causing tumor cells to die, MSCs can also limit angiogenesis by interacting with endothelial cells to cut off the flow of nutrients to the tumor cells.

According to a study, high concentrations of MSCs prevent the growth of blood vessels by releasing reactive oxygen species (ROS), whereas low concentrations of MSCs can encourage the growth of blood vessels in tumors by secreting proangiogenic substances and developing into pericytes.

Diagram A shows the gross image and histological analysis of Gil36 and Gil36/MSC co-cultured tumor section while diagram B displays the scheme of anti-angiogenesis of MSC when co-cultured with Gli36 cell. Lastly, diagram C shows the schematic figure of capillary degeneration induced by connexin-43 gap junctional channel between MSC and endothelial cell. 

TALK TO US

​If you feel we might be able to offer meaningful improvement to both your condition and your quality of life, then please reach out to schedule a free consultation with one of our in-house clinical experts. We offer consultations in both Malay and English. 

To schedule your consultation, click the button below

​During your consultation, we will: we will:

Review your medical history & recent evaluations

Explore what your treatment package might look like​

Answer any questions you have about us

Answer any questions you have about the therapies

Discuss practical next steps, ​if you feel we can effectively treat you

Review your medical history & recent evaluations

Explore what your treatment package might look like​

Answer any questions you have about us

Answer any questions you have about the therapies

Discuss practical next steps,
​if you feel we can effectively treat you