CelltiNK

A Pathway Towards Improved Health & Longevity

What is Celltink?

CelltiNK is a type of cytotoxic lymphocyte critical to the innate immune system. The role CelltiNK plays is analogous to that of cytotoxic T cells in the adaptive immune response.

CelltiNK provides rapid responses to virus-infected cells, acting within days after being administered and responding to tumour formations. Typically, immune cells detect major histocompatibility complex (MHC) present on infected cell surfaces, triggering a release of cytokines and causing tumour lysis or apoptosis.

Natural Killer Cells

What are Natural Killer Cells?

Natural killer (NK) cells are effector lymphocytes of the innate immune system that control several types of tumors and microbial infections by limiting their spread and subsequent tissue damage.

How Does it Work?

Natural Killer (NK) cells recognize abnormal or infected cells through a combination of activating receptors and inhibitory receptors.

NK cells eliminate cancer cells by releasing perforins and granzymes. When NK cells come into contact with cancer cells, they form immune synapses to deliver the killing blow. Mature NK cells are differentiated from hematopoietic stem cells in the bone marrow.

Treatable Conditions

Cancer

Cancer refers to a group of diseases characterized by abnormal cell growth that has the ability to invade or spread to other parts of the body.

Asthma

Asthma is a chronic lung disease that causes wheezing, shortness of breath, chest tightness, and coughing, particularly at night or in the early morning. It is a common long-term condition that affects both children and adults.

Viral Infection

Infection caused by the presence of a virus in the body. Depending on the virus and the person’s state of health, various viruses can infect almost any type of body tissue, from the brain to the skin.

Type 1 Diabetes

Type 1 diabetes is a chronic condition in which the immune system attacks and destroys insulin-producing cells in the pancreas. It was previously referred to as juvenile diabetes or insulin-dependent diabetes.

Rheumatoid Arthritis

An autoimmune and inflammatory disease where the immune system mistakenly attacks healthy cells in the body, causing inflammation and pain in the affected joints, often multiple joints simultaneously.

Systemic Lupus ​Erythematosus

Autoimmune disease in which the immune system mistakenly attacks its own tissues, causing widespread inflammation and tissue damage in various affected organs such as the joints, skin, brain, lungs, kidneys, and blood vessels.

What is ​Cancer ?

Cancer is a disease in which some of the body’s cells grow uncontrollably and spread to other parts of the bodyCancer can start almost anywhere in the human body.

Normally, human cells grow and multiply (through a process called cell division) to form new cells as the body needs them. When cells grow old or become damaged, they die, and new cells take their place.

Sometimes this orderly process breaks down, and abnormal or damaged cells grow and multiply when they shouldn’t. These cells may form tumors, which are lumps of tissue. Tumors can be cancerous or not cancerous (benign).

Type of cancers

Natural Killer (NK) cells recognize abnormal or infected cells through a combination of activating receptors and inhibitory receptors.

NK cells eliminate cancer cells by releasing perforins and granzymes. When NK cells come into contact with cancer cells, they form immune synapses to deliver the killing blow. Mature NK cells are differentiated from hematopoietic stem cells in the bone marrow.

Laryngeal Cancer
Melanoma Cancer
Lung Cancer
Breast Cancer
Ovarian Cancer
Stomach Cancer
Bone Cancer
Brain Cancer

Benefits of CelltiNK

Distinguish Target Cell

CelltiNK can distinguish between infected and uninfected host cells they are able to target and kill infected cells.

Rapid Responses to Virus-Infected Cells

CelltiNK provides rapid responses to virus- infected cells, acting within days after being administered and responding to tumour formations.

Works like Cytotoxic T Cells

CelltiNK is analogous to that of cytotoxic T cells in the human adaptive immune response

Publications

1. Maarof, M., Busra, M. F. M., Lokanathan, Y., Idrus, R. B. H., Rajab, N. F., & Chowdhury, S. R. (2019). Safety and efficacy of dermal fibroblast conditioned medium (DFCM) fortified collagen hydrogel as acellular 3D skin patch. Drug delivery and translational research9(1), 144-161.

2. Busra, F. M., Lokanathan, Y., Nadzir, M. M., Saim, A., Idrus, R. B. H., & Chowdhury, S. R. (2017). Attachment, proliferation, and morphological properties of human dermal fibroblasts on ovine tendon collagen scaffolds: a comparative study. The Malaysian journal of medical sciences: MJMS24(2), 33.

3. Shiplu, R. C., Jing, L. S., Muhammad, N. H., Zolkafli, N. A., Zarin, M. A., Alyani, W., … & Mothar, M. (2019). Exploring The Potential of Dermal Fibroblast Conditioned Medium on Skin Wound Healing and Anti-Ageing. Sains Malays48, 637-644.

4. Maarof, M., Chowdhury, S. R., Saim, A., Bt Hj Idrus, R., & Lokanathan, Y. (2020). Concentration Dependent Effect of Human Dermal Fibroblast Conditioned Medium (DFCM) from Three Various Origins on Keratinocytes Wound Healing. International Journal of Molecular Sciences21(8), 2929.

5. Maarof, M., Lokanathan, Y., Ruszymah, I., Saim, A., & Chowdhury, S. R. (2018). Proteomic analysis of human dermal fibroblast conditioned medium (DFCM). The protein journal37(6), 589-607