AVASCULAR NECROSIS

INTRODUCTION

Avascular necrosis : Avascular necrosis is the death of bone tissue due to a lack of blood supply

​AVASCULAR NECROSIS ​AVASCULAR NECROSIS

Diabetes is mainly caused by insufficient secretion of insulin or resistance towards the insulin and is divided into three types: type 1 diabetes, type 2 diabetes, and gestational diabetes.


Type 1 diabetes is known as insulin-dependent, as patients with this type of diabetes require daily insulin administration due to insufficient endogenous insulin as a result of autoimmune destruction on pancreatic β cells.


Type 2 diabetes is non-insulin dependent and is due to the body’s ineffective use of the insulin produced. This type of diabetes is mostly the result of being overweight, obesity, as well as lack of physical activity.
Gestational diabetes is caused by hyperglycemia in the blood glucose levels where the values exceed normal but are still insufficient to be diagnosed as diabetic and occurs during pregnancy.

SYMPTOMS SYMPTOMS

In the early stages of avascular necrosis, some people have no symptoms. However, as the condition worsens, the affected joints may only hurt when you put weight on them, and the pain may eventually be felt even when lying down.
 
The pain can range from mild to severe and usually takes time to develop. Avascular necrosis of the hip can cause pain in the groin, thigh, or buttock. In addition to the hip, the shoulder, knee, hand, and foot may also be affected. 

Avascular necrosis can occur on both sides, such as in both hips or both knees.

The following are the most common symptoms of avascular necrosis. However, each person may experience symptoms differently. Symptoms may include:

  • Minimal early joint pain
  • Increased joint pain as bone and joint begin to collapse
  • Limited range of motion due to pain

The symptoms of avascular necrosis may look like other medical conditions or bone problems. Always talk with your healthcare provider for a diagnosis. See your health care provider for ongoing pain in any joint. Seek immediate medical attention for a possible broken bone or dislocated joint.

WHAT CAUSES THE DISEASE? THE DISEASE?

​Causes

​Explanation

Joint or bone trauma

An injury, such as a dislocated joint, might damage nearby blood vessels. Cancer treatments involving radiation also can weaken bone and harm blood vessels.

Fatty deposits in blood vessels

​The fat (lipids) can block small blood vessels. This can reduce blood flow to bones.

Certain diseases

​Medical conditions, such as sickle cell anemia and Gaucher’s disease, also can lessen blood flow to bone.

CURRENT TREATMENTS TREATMENTS

The main goal of treatment is to improve functionality and stop further damage to the bone or joint. The Current Treatment that will do are: 

 Medications  Medications

Therapy Therapy

Surgical and Other Procedures Web Procedures Web

In the early stages of avascular necrosis, certain medications may help ease symptoms. The type of Medication may help Ease Symptoms: 

– Nonsteroidal anti-inflammatory drugs (NSAIDs)

– Osteoporosis drugs

– Cholesterol-lowering drugs

– Medications that open blood vessels

– Blood thinners

Your health care provider might recommend you to do : 

– Rest

– Exercises

– Electrical stimulation

Because most people don’t develop symptoms until avascular necrosis is advanced, your health care provider might recommend surgery. For example: 

– Core decompression

– Bone transplant (graft)

– Bone reshaping (osteotomy)

– Joint replacement

– Regenerative medicine treatment

WHAT WE OFFER? OFFER?

STEM CELL RESEARCH - CELLTIMAX CELLTIMAX

CelltiMax is Mesenchymal Stem Cells (MSCs) derived from human umbilical cords. Upon treatment, the cultured cells are injected intramuscularly / intravenously into the patient.

​The cells are characterized by low immunogenicity. Hence, it is very safe, tolerable, and free of side effects. It has the capability to differentiate into specialized cells with specific functions for many parts of the body. They can reduce inflammation, repair, renew, regenerate, and replace damaged cells. 

COMPARISON BETWEEN STEM CELLS AND EXOSOMES AND EXOSOMES

CRITERIAS

STEM CELLS

EXOSOMES

Definition

​​Stem cells are unspecialized cells of the human body.

 

​​Extracellular vesicles, which is the medical term for tiny bubbles that are released from stem cells.

Function

​Unique, can become any type of cell, and they act as both building blocks and repair mechanisms in your body.

​Carry genetic information and proteins to cells throughout your body, and they create paths for communication between cells.

Origins

​Donor stem cells are placed in your body and are guided into becoming specific cells in the body to replace and repair diseased cells.

​Exosomes are extracted from donated human mesenchymal stem cells (MSCs) and sterilized.

Growth Factors

​Less amount of growth factors compared to exosomes.

​Exosomes contain nearly three times the amount of growth factors. More growth factors mean a better ability to restore and revitalize target cells

Administration

  • ​IV Stem Cell Research (Intravenous administration)
  • Intrathecal (directly into the spinal canal)
  • Site injections into problem areas (Knee, hips, hands, etc)
  • Intravenous (IV) research
  • Direct injection in the treatment area​

BENEFITS OF OUR TREATMENTS OUR TREATMENTS

HOW IT WORKS? WORKS?

MSC clinical applications Avascular necrosis.

​MSCs have clinical applications for treating avascular necrosis of the hip. Avascular necrosis of the hip is a pathological condition caused by a disruption in blood supply to the femoral head. MSCs can be used to supplement the core decompression procedure, which is designed to relieve intraosseous pressure while also promoting new bone formation and angiogenesis. Some early studies using whole bone marrow transplantation have found a link between the number of osteoprogenitor cells and the outcome.

TALK TO US

​If you feel we might be able to offer meaningful improvement to both your condition and your quality of life, then please reach out to schedule a free consultation with one of our in-house clinical experts. We offer consultations in both Malay and English. 

To schedule your consultation, click the button below

​During your consultation, we will: we will:

Review your medical history & recent evaluations

Explore what your treatment package might look like​

Answer any questions you have about us

Answer any questions you have about the therapies

Discuss practical next steps, ​if you feel we can effectively treat you

Review your medical history & recent evaluations

Explore what your treatment package might look like​

Answer any questions you have about us

Answer any questions you have about the therapies

Discuss practical next steps,
​if you feel we can effectively treat you